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最后登录2019-4-10
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发表于 2017-1-27 21:05:00
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来自: 中国辽宁大连
这可能是ibrutinib治疗引起的lymphocytosis现象,无疾病进展症状的话不需要停药,大概经过8周左右时间会白细胞数值会自己降回去。
https://www.imbruvicahcp.com/mcl ... lated-lymphocytosis
Treatment-related lymphocytosis occurred in 33% of patients in the MCL trial2
Lymphocytosis is defined as ≥50% increase from baseline and above absolute lymphocyte count (ALC) of 5000/μL2
Onset of isolated lymphocytosis occurred during the first few weeks of IMBRUVICA® therapy2
Lymphocytosis resolved by a median of 8.0 weeks2
Patients with MCL who develop lymphocytosis with ALC greater than 400,000/μL have developed intracranial hemorrhage, lethargy, gait instability, and headache. However, some of these cases were in the setting of disease progression2
Isolated asymptomatic lymphocytosis may be due to the mechanism of action of IMBRUVICA® and may not be a sign of disease progression3,4 |
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