本帖最后由 橙色雨丝 于 2017-9-23 14:36 编辑
没有必要重发同样看不清的照片。周教授给你看的书可能是WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, revised 4th edition，大约160多美元一本，我舍不得花这个钱。不过《Blood》杂志上有关于这部分的介绍，简单扼要，应该是足够了：
Pediatric FL will become a definite entity in the 2016 classification but are now known as pediatric-type FL because similar lymphomas may occur in adults. It is a nodal disease characterized by large expansile highly proliferative follicles that often have prominent blastoid follicular centercells rather than classic centroblasts (or centrocytes). Some have reported a moderate number of cases as grade 1-2 of 3. BCL2 rearrangements must not be present, but there may be some BCL2 protein expression. They also lack BCL6 and MYC rearrangements with ongoing investigations of their genetic/molecular landscape. Nearly all cases arelocalized and may not require treatment other than excision. The criteria for pediatric-type FL, however, must be strictly applied to avoid underdiagnosing conventional grade 3 FL, with particular caution required before making this diagnosis in an adult. This category also excludes cases with diffuse areas(ie, foci of diffuse large B-cell lymphoma [DLBCL]). Some studies have raised the possibility that pediatric-type FL might be a “benign clonal proliferation with low malignant potential.”
儿童滤泡性淋巴瘤在2016年分类中成为一个独立的分型但是现在被命名为“儿童型滤泡性淋巴瘤”，因为同样的淋巴瘤可以发生于成人。这是一种结内疾病，其特征是较大的、扩张性的、高增殖滤泡，通常由较为明显的母细胞样滤泡中心细胞而不是经典的中心母细胞（或中心细胞）组成。有文献报告说少数病例可呈现为组织学1-2级而不是3级。必须不存在BCL2重排，但是可以有一些BCL2的表达。这些病例同样也缺乏BCL6和MYC重排，其遗传学／分子学特征尚在研究中。几乎所有的病例都是局限性的，除了手术切除之外可能不需要其它治疗。但是，必须严格的按照诊断标准来执行以避免将传统的3级滤泡性淋巴瘤误诊为儿童型滤泡性淋巴瘤，特别是针对成人的病例。这个分型也不包含那些存在弥漫区的病例（例如，局灶性弥漫大B细胞淋巴瘤）。某些研究提出了这样一种可能性，即儿童型滤泡性淋巴瘤可能是“一种具有较低的恶性潜能的良性克隆性增生”。
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发表于 2017-9-23 11:49:35
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